In the realm of structural biology, deciphering the intricate three-dimensional structures of biomacromolecules is fundamental to understanding their function and developing effective therapeutics. Two powerful techniques stand at the forefront of this endeavor: cryo-electron microscopy (cryo-EM) and X-ray crystallography. While both aim to reveal the atomic or near-atomic arrangements of biological entities, they operate on distinct principles and offer unique advantages. Choosing the right path for your structural investigation is crucial for success. Shuimu BioSciences, a leading commercial platform in Asia for cryo-EM structure determination, also offers comprehensive protein expression, purification, and crystallographic analysis services. This article will explore the nuances of CryoEM services, particularly those offered by Shuimu BioSciences, and briefly touch upon X-ray crystallography to help guide your decision. For more detailed information on our services and to discuss your specific project needs, please visit https://shuimubio.com/ and contact our marketing team.
Cryo-electron microscopy (cryo-EM) has revolutionized structural biology by enabling the visualization of biomacromolecules in a near-native, hydrated state. This is achieved by rapidly freezing purified samples in a thin film of vitreous ice, preserving their structure and minimizing radiation damage during imaging. Shuimu BioSciences stands as a leader in this field, boasting the world’s largest commercial cryo-EM platform with two 300 kV instruments in Beijing and six in Hangzhou. These state-of-the-art facilities are equipped with advanced technologies, including high-performance detectors, energy filters, spherical aberration correctors, and phase plates, ensuring the highest quality imaging.
Shuimu BioSciences offers a comprehensive suite of Cryo-EM Services, including:
Shuimu BioSciences's Cryo-EM Center is led by a core team of world-class experts in life sciences, computational science, IT, and the pharmaceutical sectors. Our experienced EM scientists leverage deep research and technical heritage in structural biology from Tsinghua University to establish efficient, advanced workflows for both experimental procedures and data analysis. We have resolved more than 150 structures with a best resolution of 1.8 Å. Our commitment to quality is underscored by the fact that our electron microscopes maintain over 330 days of available machine time annually and a fault-free operation rate greater than 97%. Numerous research results supported by our platform have been published in top international journals, covering structures of ion channels, GPCRs, antigen-antibody complexes, and more.
For more information on how our Cryo-EM services can advance your research, please visit https://shuimubio.com/ and contact our marketing team to discuss your project.
In contrast to cryo-EM, X-ray crystallography requires the target molecule to be crystallized into a highly ordered three-dimensional lattice. When these crystals are exposed to X-rays, they diffract the radiation in a pattern that can be used to reconstruct the electron density map of the molecule, ultimately revealing its structure. Shuimu BioSciences offers a One-Stop Crystallographic Analysis service, covering protein expression, purification, crystallization, data collection, and final structure analysis. This service has been successfully applied to challenging targets such as KRAS and the SARS-CoV-2 M protein. By revealing high-resolution structures of antibody-antigen complexes, X-ray crystallography provides deep insights into their interactions, aiding in antibody design and drug development.
For inquiries regarding our X-ray Crystallography services, please visit https://shuimubio.com/ and contact our marketing team.
The choice between cryo-EM and X-ray crystallography often depends on the nature of the biomolecule and the specific research question.
Shuimu BioSciences provides both Cryo-EM and Crystallography services, recognizing that the optimal approach varies depending on the project. Our expert team can provide consultation to help you determine the most suitable method for your research goals. Visit https://shuimubio.com/ and contact our marketing team for personalized guidance.
Choosing Shuimu BioSciences for your Cryo-EM Services offers several key advantages:
To learn more about the advantages of partnering with Shuimu BioSciences for your Cryo-EM projects, please visit https://shuimubio.com/ and contact our marketing team.
Both cryo-EM and X-ray crystallography are indispensable tools in the pursuit of structural insights. Cryo-EM's ability to study challenging samples in a near-native state has opened new frontiers in structural biology, and Shuimu BioSciences is at the forefront of providing cutting-edge CryoEM Services. Whether your research involves large protein complexes, membrane proteins, or other difficult-to-crystallize biomolecules, our state-of-the-art facilities, expert team, and comprehensive service offerings can help you achieve your structural biology goals. For further information and to discuss your specific project requirements, we encourage you to visit https://shuimubio.com/ and contact our dedicated marketing team today. We look forward to helping you choose the right path for your structural biology journey.